Adrian Monk was one of San Francisco's finest detectives, but all that ended when his wife was murdered. He developed a severe case of O.C.D. (obsessive compulsive disorder) and now he can hardly function in society without help. Even with O.C.D., he has a brilliant mind, and he notices things about a crime scene that are often overlooked. He's a modern Sherlock Holmes, just with a few issues. He'd love to get back onto the police force, but his fear of germs, heights, flying, and countless other things make that a bit hard. For now he'll settle for being a consultant, knowing that one day he'll have another chance to prove himself. When he's called to help Captain Stottlemeyer he's accompanied by his assistant, Natalie, who helps him overcome the many obstacles he faces (like shaking hands, dirty areas and remembering where he is).