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This natural product contains no drugs. It is very palatable with a pleasant caramel taste. Simply squirt the correct amount either on your dogs food or in their mouths. Calmeze can be used as a once off treatment about an hour before anxiety producing events or it actually works much better if administered daily. It contains vitamins and amino acids that promote relaxation. It can be used in stressfulsituations as well as to relieveanxietyas a result of weaning, separation, transport to a new environment, kenneling, hospitalisation and fear of travel. One bottle of 250ml should last about 2 months for a small dog like a Jack Russel.